Publications

Next-generation sequencing-based evaluation of the actionable landscape of genomic alterations in solid tumors: the 'MOZART' prospective observational study

Oncologist. 2024 Aug 23:oyae206. doi: 10.1093/oncolo/oyae206. Epub ahead of print. PMID: 39177668.

2024-08-23

Schettini F, Sirico M, Loddo M, Williams GH, Hardisty KM, Scorer P, Thatcher R, Rivera P, Milani M, Strina C, Ferrero G, Ungari M, Bottin C, Zanconati F, de Manzini N, Aguggini S, Tancredi R, Fiorio E, Fioravanti A, Scaltriti M, Generali D.

Impact of Decalcification, Cold Ischemia, and Deglycosylation on Performance of Programmed Cell Death Ligand-1 Antibodies With Different Binding Epitopes: Comparison of 7 Clones

Mod Pathol, May 23;36(9).

https://www.modernpathology.org/article/S0893-3952(23)00125-4/fulltext

2023-05-23

Nicola L Lawson, Paul W Scorer, Gareth H Williams, Michel E Vandenberghe, Marianne J Ratcliffe, Craig Barker

Utilisation of semiconductor sequencing for detection of actionable fusions in solid tumours

PLoS One . 2022 Aug 19;17(8):e0246778. doi: 10.1371/journal.pone.0246778. eCollection 2022.

https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0246778

2022-08-19

Marco Loddo, Keeda-Marie Hardisty, Alexander Llewelyn, Tiffany Haddow, Robert Thatcher, Gareth Williams

Utilisation of semiconductor sequencing for the detection of predictive biomarkers in glioblastoma

Published: March 25, 2022 DOI:

https://doi.org/10.1371/journal.pone.0245817

2022-03-25

Gareth H Williams, Alexander Llewelyn, Robert Thatcher, Keeda-Marie Hardisty, Marco Loddo

SARS-CoV-2 testing and sequencing for international arrivals reveals significant cross border transmission of high risk variants into the United Kingdom

EClinical Medicine by the Lancet Published:July 14, 2021 DOI:

https://doi.org/10.1016/j.eclinm.2021.101021

2021-07-14

Gareth H Williams, Alexander Llewelyn, Ruben Brandao, Kaiya Chowdhary,Keeda-Marie Hardisty, Marco Loddo (2021)

Clinical, Radiometabolic and Immunologic Effects of Olaparib in Locally Advanced Triple Negative Breast Cancer: The OLTRE Window of Opportunity Trial

Front Oncol. 2021; 11: 686776. Published online 2021 Jun 28. doi:

https://doi.org/10.3389/fonc.2021.686776

2021-06-28

Alfredo Molteni, Alice Bruson, Carla Strina, Carlo Azzini, Daniele Generali, Davide Cerra, Elena Marasco, Elisa Zago, Fabiola Giudici, Francesco Schettini, Gareth H Williams, Giovanni Scambia, Giuseppina Barbieri, Giuseppina Ferrero, Ida Paris, Luciano Xumerle, Manuela Milani, Marco Loddo, Marco Ungari, Maria Chiara Lazzari, Maria Rosa Cappelletti, Marianna Sirico, Nicoletta Ziglioli, Ottavia Bernocchi, Sergio Aguggini, Silvia Paola Corona, Valeria Cervoni

The actionable genomic mutational landscape in solid tumours

J Clin Oncol 38: 2020 (suppl; abstr e13642) DOI:

https://doi.org/10.1200/JCO.2020.38.15_suppl.e13642

2020-05-25

Loddo M, Hardisty KM, Thatcher RP, Haddow TE, Williams GH (2020)

Druggable fusion gene landscape in solid tumors

J Clin Oncol 38: 2020 (suppl; abstr e13517) DOI:

https://doi.org/10.1200/JCO.2020.38.15_suppl.e13517

2020-05-25

Williams GH, Thatcher RP, Nevado B, Haddow TE, Hardisty KM, Loddo M (2020)

Immunofocus-PD-L1 high throughput quantitative next generation sequencing assay

J Clin Oncol 38: 2020 (suppl; abstr e13521) DOI:

https://doi.org/10.1200/JCO.2020.38.15_suppl.e13521

2020-05-25

Williams GH, Thatcher RP, Haddow TE, Hardisty KM, Loddo M (2020)

Inter-observer Reliability of Programmed Cell Death Ligand-1 Scoring Using the VENTANA PD-L1 (SP263) Assay in Non-Small Cell Lung Cancer

J Thorac Oncol. 2019 Nov 25. pii: S1556-0864(19)33664-0. doi:

https://doi.org/10.1016/j.jtho.2019.11.010

2019-11-25

Williams GH, Nicholson AG, Snead DRJ, Thunnissen E, Lantuejoul S, Cane P, Kerr KM, Loddo M, Scott MLJ, Scorer PW, Barker C. (2019)

Mapping the binding sites of antibodies utilized in programmed cell death ligand-1 predictive immunohistochemical assays for use with immuno-oncology therapies

Mod Pathol. 2019 Sep 26. doi [Epub ahead of print] Erratum in: Mod Pathol. 2019 Oct:

https://doi.org/10.1038/s41379-019-0372-z

2019-09-26

Lawson NL, Dix CI, Scorer PW, Stubbs CJ, Wong E, Hutchinson L, McCall EJ, Schimpl M, DeVries E, Walker J, Williams GH, Hunt J, Barker C. (2019)

Assessment of PD-L1 mRNA and protein expression in non-small cell lung cancer, head and neck squamous cell carcinoma and urothelial carcinoma tissue specimens using RNAScope and immunohistochemistry.

PLoS ONE 14(4): e0215393

2019-04-15

David Jonathan Duncan ,Marietta Scott,Paul Scorer et al ()

Inter-rater reliability of programmed death ligand 1 (PD-L1) scoring using the VENTANA PD-L1 (SP263) assay in Non-Small-Cell-Lung Cancer (NSCLC).

Annals of Oncology (2018) 29 (suppl_8): viii14-viii57. 10.1093/annonc/mdy269

2018-10-19

G.H. Williams, A.G. Nicholson, D.R.J. Snead, E. Thunnissen, S. Lantuejoul, P. Cane, K.M. Kerr, M. Loddo, M. Scott, P.W. Scorer, C. Barker

Consistency of tumor and immune cell programmed cell death ligand-1 expression within and between tumor blocks using the VENTANA SP263 assay

Diagnostic Pathology, (2018) 13:47 DOI:

https://doi.org/10.1186/s13000-018-0725-9

2018-07-24

Paul Scorer, Marietta Scott, Nicola Lawson et al (2018)

DNA replication licensing factor MCM2, geminin, and Ki67 define proliferative state and are linked with survival in oral squamous cell carcinoma

Eur J Oral Sci. 2018 Jun;126(3):186-196. doi:

https://doi.org/10.1111/eos.12420

2018-06-11

Al-Hazmi N, Alhazzazi T, Williams G, Stoeber K, Al-Dabbagh R

Immunophenotypic analysis of cell cycle status in acute myeloid leukaemia: relationship to cytogenetics, genotype and clinical outcome

Br J Haematol. 2018 May;181(4):486-494 [Epub 2018 Apr 20.]

https://doi.org/10.1111/bjh.15211

2018-05-14

Sellar RS, Gale RE, Khwaja A, Garbowski M, Loddo M, Stoeber K, Williams GH, Linch DC

Relevance of deep learning to facilitate the diagnosis of HER2 status in breast cancer.

Nature – Scientific Reports, April 2017, 7, 45938 DOI:

https://doi.org/10.1038/srep45938

2017-04-03

Michel E. Vandenberghe, Marietta L. J. Scott, Paul W. Scorer et al (2017)

A novel p53-Cdc7 link induced by genotoxic stress

Cell Cycle, DOI:

https://doi.org/10.1080/15384101.2017.1304746

2017-03-15

Hisao Masai

Agreement between Programmed Cell Death Ligand-1 Diagnostic Assays across Multiple Protein Expression Cut-Offs in Non-Small Cell Lung Cancer

Clinical Cancer Research, January 2017; 16-2375 DOI:

https://doi.org/10.1158/1078-0432.ccr-16-2375

2017-01-04

Marianne J Ratcliffe, Alan Sharpe, Anita Midha et al (2017)

A comparative study of PD-L1 diagnostic assays in squamous cell carcinoma of the head and neck (SCCHN)

Annals of Oncology; 27 (suppl_6): 955PD DOI:

https://doi.org/10.1093/annonc/mdw376.07

2016-10-01

J. Ratcliffe, A. Sharpe, M. Rebelatto et al ()

Integration of next-generation sequencing in clinical diagnostic molecular pathology laboratories for analysis of solid tumours; an expert opinion on behalf of IQN Path ASBL

Virchows Arch (2016). doi:

https://doi.org/10.1007/s00428-016-2025-7

2016-09-27

Zandra C Deans, Jose Luis Costa, Ian Cree, Els Dequeker, Anders Edsjö, Shirley Henderson, Michael Hummel, Marjolijn JL Ligtenberg, Marco Loddo, Jose Carlos Machado, Antonio Marchetti, Katherine Marquis, Joanne Mason, Nicola Normanno, Etienne Rouleau, Ed Schuuring, Keeda-Marie Snelson, Erik Thunnissen, Bastiaan Tops, Gareth Williams, Han van Krieken, Jacqueline A Hall, On behalf of IQN Path ASBL

p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress

Cell Cycle. 2016 Sep 9:0 DOI:

https://doi.org/10.1080/15384101.2016.1231281

2016-09-09

Tudzarova S, Mulholland P, Dey A, Stoeber K, Okorokov AL, Williams GH

Cell cycle status in AML blast cells from peripheral blood, bone marrow aspirates and trephines and implications for biological studies and treatment

Br J Haematol. 2016 Apr 8. doi:

https://doi.org/10.1111/bjh.14055

2016-04-08

Sellar RS, Fraser L, Khwaja A, Gale RE, Marafioti T, Akarca A, Hubank M, Brooks T, Stoeber K,Williams G, Linch DC

Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpoint

Oncotarget. 2016 Feb 23. doi:

https://doi.org/10.18632/oncotarget.7611

2016-02-23

Huggett MT, Tudzarova S, Proctor I, Loddo M, Keane MG, Stoeber K, Williams GH, Pereira SP.

Do Cell-Cycle Phase-Specific Markers Predict Disease Grade, Stage, and Outcome in Cervical Carcinoma?

Int J Gynecol Cancer. 2015 Jul;25(6):1066-72

2015-07-06

Kuku S, Proctor I, Loddo M, Kadalayil L, KhoshZaban M, Ledermann J, McCormack M.

Pregnancy-associated plasma protein A regulates mitosis and is epigenetically silenced in breast cancer

J Pathol. 2014 Aug;233(4):344-56.

2014-08-01

Loddo M, Andryszkiewicz J, Rodriguez-Acebes S, Stoeber K, Jones A, Dafou D, Apostolidou S, Wollenschlaeger A, Widschwendter M, Sainsbury R, Tudzarova S, Williams GH.

Subcellular proteomics reveals a role for nucleo-cytoplasmic trafficking at the DNA replication origin activation checkpoint

J Proteome Res. 2013 Mar 1;12(3):1436-53

2013-03-01

Mulvey CM, Tudzarova S, Crawford M, Williams GH, Stoeber K, Godovac-Zimmermann J

Bladder cancer diagnosis and identification of clinically significant disease by combined urinary detection of Mcm5 and nuclear matrix protein 22

PLoS One. 2012;7(7):e40305

2012-07-09

Kelly JD, Dudderidge TJ, Wollenschlaeger A, Okoturo O, Burling K, Tulloch F, Halsall I, Prevost T, Prevost AT, Vasconcelos JC, Robson W, Leung HY, Vasdev N, Pickard RS, Williams GH, Stoeber K.

The cell cycle and cancer

J Pathol. 2012 Jan;226(2):352-64.

2012-01-16

Williams GH, Stoeber K.

Exploring the interaction between siRNA and the SMoC biomolecule transporters: implications for small molecule-mediated delivery of siRNA

Chem Biol Drug Des. 2012 Jan;79(1):9-21.

2012-01-02

Gooding M, Tudzarova S, Worthington RJ, Kingsbury SR, Rebstock AS, Dube H, Simone MI, Visintin C, Lagos D, Quesada JM, Laman H, Boshoff C, Williams GH, Stoeber K, Selwood DL.

Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5278-83

2011-03-29

Tudzarova S, Colombo SL, Stoeber K, Carcamo S, Williams GH, Moncada S.

Molecular architecture of the DNA replication origin activation checkpoint

EMBO J. 2010 Oct 6;29(19):3381-94.

2010-10-06

Tudzarova S, Trotter MW, Wollenschlaeger A, Mulvey C, Godovac-Zimmermann J, Williams GH, Stoeber K.

Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers

Am J Pathol. 2010 Oct;177(4):2034-45.

2010-10-04

Rodriguez-Acebes S, Proctor I, Loddo M, Wollenschlaeger A, Rashid M, Falzon M, Prevost AT, Sainsbury R, Stoeber K, Williams GH.

Quantitative Proteomics Reveals a “Poised Quiescence” Cellular State after Triggering the DNA Replication Origin Activation Checkpoint

J Proteome Res . 2010 Oct 1;9(10):5445-60. doi: 10.1021/pr100678k.

https://pubs.acs.org/doi/10.1021/pr100678k

2010-10-01

Claire Mulvey, Slavica Tudzarova, Mark Crawford, Gareth H. Williams, Kai Stoeber and Jasminka Godovac-Zimmermann

Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments

Br J Cancer. 2010 Aug 24;103(5):701-7.

2010-08-24

Dudderidge TJ, Kelly JD, Wollenschlaeger A, Okoturo O, Prevost T, Robson W, Leung HY, Williams GH, Stoeber K.

Standard Reference Material: Cell Line Development and Use of Reference Cell Lines as Standards for External Quality Assurance of Her2 IHC and ISH Testing. Antigen Retrieval Immunohistochemistry Based Research and Diagnostics (Book)

First Edition; 2010; Chapter 6; pp.101-122 DOI:

https://doi.org/10.1002/9780470875612.ch6

2010-08-02

Shan-Rong Shi and Clive R. Taylor (2010)

Biomarkers in bladder cancer

Histopathology . 2010 Jul;57(1):1-13. doi: 10.1111/j.1365-2559.2010.03592.x.

https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2559.2010.03592.x

2010-07-12

Ian Proctor, Kai Stoeber, Gareth H Williams

DNA replication licensing factors and aneuploidy are linked to tumor cell cycle state and clinical outcome in penile carcinoma

Clin Cancer Res. 2009 Dec 1;15(23):7335-44.

2009-12-01

Kayes OJ, Loddo M, Patel N, Patel P, Minhas S, Ambler G, Freeman A, Wollenschlaeger A, Ralph DJ, Stoeber K, Williams GH.

Phospho-STAT5 and phospho-Akt expression in chronic myeloproliferative neoplasms

British Journal of Haematology, 2009, Vol. 147: p495-506 DOI:

https://doi.org/10.1111/j.1365-2141.2009.07870.x

2009-11-09

L. F. Grimwade, L. Happerfield, C. Tristram Lisa Happerfield et al (2009)

Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma

Clin Cancer Res. 2009 Apr 1;15(7):2417-25.

2009-04-01

Kulkarni AA, Kingsbury SR, Tudzarova S, Hong HK, Loddo M, Rashid M, Rodriguez-Acebes S, Prevost AT, Ledermann JA, Stoeber K, Williams GH.

Cell-cycle-phase progression analysis identifies unique phenotypes of major prognostic and predictive significance in breast cancer

Br J Cancer. 2009 Mar 24;100(6):959-70.

2009-03-24

Loddo M, Kingsbury SR, Rashid M, Proctor I, Holt C, Young J, El-Sheikh S, Falzon M, Eward KL, Prevost T, Sainsbury R, Stoeber K, Williams GH.

Identification of an arginine-rich motif in human papillomavirus type 1 E1;E4 protein necessary for E4-mediated inhibition of cellular DNA synthesis in vitro and in cells

J Virol 82:9056-9064

2008-09-01

Roberts S, Kingsbury SR, Stoeber K, Knight GL Gallimore PH & Williams GH

Modular assembly using sequential palladium coupling gives easy access to the SMoC class of cellular transporters

Chembiochem. 2008 Jul 21;9(11):1787-96.

2008-07-21

Rebstock AS, Visintin C, Leo E, Garcia Posada C, Kingsbury SR, Williams GH, Stoeber K, Selwood DL.

Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in bile aspirates

Br J Cancer. 2008 May 6;98(9):1548-54.

2008-05-06

Ayaru L, Stoeber K, Webster GJ, Hatfield AR, Wollenschlaeger A, Okoturo O, Rashid M, Williams G, Pereira SP.

Cell cycle markers in clinical oncology

Curr Opin Cell Biol. 2007 Dec;19(6):672-9.

2007-12-03

Williams GH, Stoeber K.

DNA replication licensing factors and aurora kinases are linked to aneuploidy and clinical outcome in epithelial ovarian carcinoma.

Clin Cancer Res. 2007 Oct 15;13(20):6153-61.

2007-10-15

Kulkarni AA, Loddo M, Leo E, Rashid M, Eward KL, Fanshawe TR, Butcher J, Frost A, Ledermann JA, Williams GH, Stoeber K.

Hexameric ring structure of human MCM10 DNA replication factor

EMBO Rep. 2007 Oct;8(10):925-30.

2007-10-11

Okorokov AL, Waugh A, Hodgkinson J, Murthy A, Hong HK, Leo E, Sherman MB, Stoeber K, Orlova EV, Williams GH.

Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancer

Br J Cancer. 2007 May 7;96(9):1384-93.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360172/

2007-05-07

Dudderidge TJ, McCracken SR, Loddo M, Fanshawe TR, Kelly JD, Neal DE, Leung HY, Williams GH, Stoeber K.

Small-molecule mimics of an alpha-helix for efficient transport of proteins into cells

Nat Methods. 2007 Feb;4(2):153-9.

2007-02-21

Okuyama M, Laman H, Kingsbury SR, Visintin C, Leo E, Eward KL, Stoeber K, Boshoff C, Williams GH, Selwood DL.

Novel markers of cell kinetics to evaluate progression from cirrhosis to hepatocellular carcinoma

Liver Int. 2006 May;26(4):424-32.

2006-05-12

Quaglia A, McStay M, Stoeber K, Loddo M, Caplin M, Fanshawe T, Williams G, Dhillon A.