Publications

Improved cervical smear assessment using antibodies against proteins that regulate DNA replication

Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14932-7.

Williams GH, Romanowski P, Morris L, Madine M, Mills AD, Stoeber K, Marr J, Laskey RA, Coleman N.

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system

EMBO J. 1998 Dec 15;17(24):7219-29.

Stoeber K, Mills AD, Kubota Y, Krude T, Romanowski P, Marheineke K, Laskey RA, Williams GH.

The Hormonal Receptor Status of Uterine Carcinosarcomas (Mixed Mullerian Tumours): an Immunohistochemical study

Journal of Clinical Pathology, April 1997, Vol. 50: No.4, p328-331 DOI:

https://dx.doi.org/10.1136%2Fjcp.50.4.328

A.C. Ansink, P.A. Cross, P. Scorer et al (1997)

Improved cervical smear assessment using antibodies against proteins that regulate DNA replication

Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14932-7.

Williams GH, Romanowski P, Morris L, Madine M, Mills AD, Stoeber K, Marr J, Laskey RA, Coleman N.

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system

EMBO J. 1998 Dec 15;17(24):7219-29.

Stoeber K, Mills AD, Kubota Y, Krude T, Romanowski P, Marheineke K, Laskey RA, Williams GH.

Clinical applications of a novel mammalian cell-free DNA replication system

Br J Cancer. 1999 Jul;80 Suppl 1:20-4.

Williams G, Stoeber K.

Minichromosome maintenance proteins as biological markers of dysplasia and malignancy

Clin Cancer Res. 1999 Aug;5(8):2121-32.

Freeman A, Morris LS, Mills AD, Stoeber K, Laskey RA, Williams GH, Coleman N.

Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine

Lancet. 1999 Oct 30;354(9189):1524-5.

Stoeber K, Halsall I, Freeman A, Swinn R, Doble A, Morris L, Coleman N, Bullock N, Laskey RA, Hales CN, Williams GH.

DNA replication licensing and human cell proliferation

J Cell Sci. 2001 Jun;114(Pt 11):2027-41.

Stoeber K, Tlsty TD, Happerfield L, Thomas GA, Romanov S, Bobrow L, Williams ED, Williams GH.

Use of the Monoclonal Antibody DAKO-ERβ (8D5-1) to Measure Oestrogen Receptor Beta in Breast Cancer Cells

Cytometry, 2001, Vol. 45: p65-72 DOI:

https://doi.org/10.1002/1097-0320(20010901)45:1%3C65::aid-cyto1145%3E3.0.co;2-8

F. Girdler, D.A. Browell W.J. Cunliffe et al (2001)

Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer

Clin Cancer Res. 2001 Sep;7(9):2712-8.

Meng MV, Grossfeld GD, Williams GH, Dilworth S, Stoeber K, Mulley TW, Weinberg V, Carroll PR, Tlsty TD.

Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett’s mucosa

Gut. 2002 Mar;50(3):373-7.

Going JJ, Keith WN, Neilson L, Stoeber K, Stuart RC, Williams GH.

Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments

J Natl Cancer Inst. 2002 Jul 17;94(14):1071-9.

Stoeber K, Swinn R, Prevost AT, de Clive-Lowe P, Halsall I, Dilworth SM, Marr J, Turner WH, Bullock N, Doble A, Hales CN, Williams GH.

Diagnosis of oesophageal cancer by detection of minichromosome maintenance 5 protein in gastric aspirates

Br J Cancer. 2004 Aug 16;91(4):714-9.

Williams GH, Swinn R, Prevost AT, De Clive-Lowe P, Halsall I, Going JJ, Hales CN, Stoeber K, Middleton SJ.

Molecular structure of human geminin

Nat Struct Mol Biol. 2004 Oct;11(10):1021-2.

Okorokov AL, Orlova EV, Kingsbury SR, Bagneris C, Gohlke U, Williams GH, Stoeber K.

DNA replication licensing in peripheral B-cell lymphoma

J Pathol. 2005 Feb;205(3):318-28.

Obermann EC, Eward KL, Dogan A, Paul EA, Loddo M, Munson P, Williams GH, Stoeber K.

DNA replication licensing in somatic and germ cells

J Cell Sci. 2004 Nov 15;117(Pt 24):5875-86.

Eward KL, Obermann EC, Shreeram S, Loddo M, Fanshawe T, Williams C, Jung HI, Prevost AT, Blow JJ, Stoeber K, Williams GH.

Mcm2, Geminin, and KI67 define proliferative state and are prognostic markers in renal cell carcinoma

Clin Cancer Res. 2005 Apr 1;11(7):2510-7.

Dudderidge TJ, Stoeber K, Loddo M, Atkinson G, Fanshawe T, Griffiths DF, Williams GH.

DNA replication licensing in peripheral B-cell lymphoma

J Pathol. 2005 Feb;205(3):318-28.

Obermann EC, Eward KL, Dogan A, Paul EA, Loddo M, Munson P, Williams GH, Stoeber K.

Repression of DNA replication licensing in quiescence is independent of geminin and may define the cell cycle state of progenitor cells

Exp Cell Res. 2005 Sep 10;309(1):56-67.

Kingsbury SR, Loddo M, Fanshawe T, Obermann EC, Prevost AT, Stoeber K, Williams GH.

DNA replication licensing and cell cycle kinetics of normal and neoplastic breast

Br J Cancer. 2005 Nov 28;93(11):1295-300.

Shetty A, Loddo M, Fanshawe T, Prevost AT, Sainsbury R, Williams GH, Stoeber K.

Novel markers of cell kinetics to evaluate progression from cirrhosis to hepatocellular carcinoma

Liver Int. 2006 May;26(4):424-32.

Quaglia A, McStay M, Stoeber K, Loddo M, Caplin M, Fanshawe T, Williams G, Dhillon A.

Small-molecule mimics of an alpha-helix for efficient transport of proteins into cells

Nat Methods. 2007 Feb;4(2):153-9.

Okuyama M, Laman H, Kingsbury SR, Visintin C, Leo E, Eward KL, Stoeber K, Boshoff C, Williams GH, Selwood DL.

DNA replication licensing, and survival are linked in prostate cancer

Br J Cancer. 2007 May 7;96(9):1384-93.

Dudderidge TJ, McCracken SR, Loddo M, Fanshawe TR, Kelly JD, Neal DE, Leung HY, Williams GH, Stoeber K.

Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancer

Br J Cancer. 2007 May 7;96(9):1384-93.

Dudderidge TJ, McCracken SR, Loddo M, Fanshawe TR, Kelly JD, Neal DE, Leung HY, Williams GH, Stoeber K.

Hexameric ring structure of human MCM10 DNA replication factor

EMBO Rep. 2007 Oct;8(10):925-30.

Okorokov AL, Waugh A, Hodgkinson J, Murthy A, Hong HK, Leo E, Sherman MB, Stoeber K, Orlova EV, Williams GH.

DNA replication licensing factors and aurora kinases are linked to aneuploidy and clinical outcome in epithelial ovarian carcinoma.

Clin Cancer Res. 2007 Oct 15;13(20):6153-61.

Kulkarni AA, Loddo M, Leo E, Rashid M, Eward KL, Fanshawe TR, Butcher J, Frost A, Ledermann JA, Williams GH, Stoeber K.

Cell cycle markers in clinical oncology

Curr Opin Cell Biol. 2007 Dec;19(6):672-9.

Williams GH, Stoeber K.

Identification of an arginine-rich motif in human papillomavirus type 1 E1;E4 protein necessary for E4-mediated inhibition of cellular DNA synthesis in vitro and in cells

J Virol 82:9056-9064

Roberts S, Kingsbury SR, Stoeber K, Knight GL Gallimore PH & Williams GH

Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in bile aspirates

Br J Cancer. 2008 May 6;98(9):1548-54.

Ayaru L, Stoeber K, Webster GJ, Hatfield AR, Wollenschlaeger A, Okoturo O, Rashid M, Williams G, Pereira SP.

Modular assembly using sequential palladium coupling gives easy access to the SMoC class of cellular transporters

Chembiochem. 2008 Jul 21;9(11):1787-96.

Rebstock AS, Visintin C, Leo E, Garcia Posada C, Kingsbury SR, Williams GH, Stoeber K, Selwood DL.

Cell-cycle-phase progression analysis identifies unique phenotypes of major prognostic and predictive significance in breast cancer

Br J Cancer. 2009 Mar 24;100(6):959-70.

Loddo M, Kingsbury SR, Rashid M, Proctor I, Holt C, Young J, El-Sheikh S, Falzon M, Eward KL, Prevost T, Sainsbury R, Stoeber K, Williams GH.

Phospho-STAT5 and phospho-Akt expression in chronic myeloproliferative neoplasms

British Journal of Haematology, 2009, Vol. 147: p495-506 DOI:

https://doi.org/10.1111/j.1365-2141.2009.07870.x

L. F. Grimwade, L. Happerfield, C. Tristram Lisa Happerfield et al (2009)

Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma

Clin Cancer Res. 2009 Apr 1;15(7):2417-25.

Kulkarni AA, Kingsbury SR, Tudzarova S, Hong HK, Loddo M, Rashid M, Rodriguez-Acebes S, Prevost AT, Ledermann JA, Stoeber K, Williams GH.

DNA replication licensing factors and aneuploidy are linked to tumor cell cycle state and clinical outcome in penile carcinoma

Clin Cancer Res. 2009 Dec 1;15(23):7335-44.

Kayes OJ, Loddo M, Patel N, Patel P, Minhas S, Ambler G, Freeman A, Wollenschlaeger A, Ralph DJ, Stoeber K, Williams GH.

Standard Reference Material: Cell Line Development and Use of Reference Cell Lines as Standards for External Quality Assurance of Her2 IHC and ISH Testing. Antigen Retrieval Immunohistochemistry Based Research and Diagnostics (Book)

First Edition; 2010; Chapter 6; pp.101-122 DOI:

https://doi.org/10.1002/9780470875612.ch6

Shan-Rong Shi and Clive R. Taylor (2010)

Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments

Br J Cancer. 2010 Aug 24;103(5):701-7.

Dudderidge TJ, Kelly JD, Wollenschlaeger A, Okoturo O, Prevost T, Robson W, Leung HY, Williams GH, Stoeber K.

Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers

Am J Pathol. 2010 Oct;177(4):2034-45.

Rodriguez-Acebes S, Proctor I, Loddo M, Wollenschlaeger A, Rashid M, Falzon M, Prevost AT, Sainsbury R, Stoeber K, Williams GH.

Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle

Proc Natl Acad Sci U S A. 2011 Mar 29;108(13):5278-83

Tudzarova S, Colombo SL, Stoeber K, Carcamo S, Williams GH, Moncada S.

Molecular architecture of the DNA replication origin activation checkpoint

EMBO J. 2010 Oct 6;29(19):3381-94.

Tudzarova S, Trotter MW, Wollenschlaeger A, Mulvey C, Godovac-Zimmermann J, Williams GH, Stoeber K.

Exploring the interaction between siRNA and the SMoC biomolecule transporters: implications for small molecule-mediated delivery of siRNA

Chem Biol Drug Des. 2012 Jan;79(1):9-21.

Gooding M, Tudzarova S, Worthington RJ, Kingsbury SR, Rebstock AS, Dube H, Simone MI, Visintin C, Lagos D, Quesada JM, Laman H, Boshoff C, Williams GH, Stoeber K, Selwood DL.

The cell cycle and cancer

J Pathol. 2012 Jan;226(2):352-64.

Williams GH, Stoeber K.

Bladder cancer diagnosis and identification of clinically significant disease by combined urinary detection of Mcm5 and nuclear matrix protein 22

PLoS One. 2012;7(7):e40305

Kelly JD, Dudderidge TJ, Wollenschlaeger A, Okoturo O, Burling K, Tulloch F, Halsall I, Prevost T, Prevost AT, Vasconcelos JC, Robson W, Leung HY, Vasdev N, Pickard RS, Williams GH, Stoeber K.

Subcellular proteomics reveals a role for nucleo-cytoplasmic trafficking at the DNA replication origin activation checkpoint

J Proteome Res. 2013 Mar 1;12(3):1436-53

Mulvey CM, Tudzarova S, Crawford M, Williams GH, Stoeber K, Godovac-Zimmermann J

Huggett MT, Tudzarova S, Proctor I, Loddo M, Keane MG, Stoeber K, Williams GH, Pereira SP.

Cell cycle status in AML blast cells from peripheral blood, bone marrow aspirates and trephines and implications for biological studies and treatment

Br J Haematol. 2016 Apr 8. doi:

https://doi.org/10.1111/bjh.14055

Sellar RS, Fraser L, Khwaja A, Gale RE, Marafioti T, Akarca A, Hubank M, Brooks T, Stoeber K,Williams G, Linch DC

p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress

Cell Cycle. 2016 Sep 9:0 DOI:

https://doi.org/10.1080/15384101.2016.1231281

Tudzarova S, Mulholland P, Dey A, Stoeber K, Okorokov AL, Williams GH

A comparative study of PD-L1 diagnostic assays in squamous cell carcinoma of the head and neck (SCCHN)

Annals of Oncology; 27 (suppl_6): 955PD DOI:

https://doi.org/10.1093/annonc/mdw376.07

J. Ratcliffe, A. Sharpe, M. Rebelatto et al ()

Publications

Improved cervical smear assessment using antibodies against proteins that regulate DNA replication

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system

The Hormonal Receptor Status of Uterine Carcinosarcomas (Mixed Mullerian Tumours): an Immunohistochemical study

Improved cervical smear assessment using antibodies against proteins that regulate DNA replication

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system

Clinical applications of a novel mammalian cell-free DNA replication system

Minichromosome maintenance proteins as biological markers of dysplasia and malignancy

Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine

DNA replication licensing and human cell proliferation

Use of the Monoclonal Antibody DAKO-ERβ (8D5-1) to Measure Oestrogen Receptor Beta in Breast Cancer Cells

Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer

Aberrant expression of minichromosome maintenance proteins 2 and 5, and Ki-67 in dysplastic squamous oesophageal epithelium and Barrett’s mucosa

Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments

Diagnosis of oesophageal cancer by detection of minichromosome maintenance 5 protein in gastric aspirates

Molecular structure of human geminin

DNA replication licensing in peripheral B-cell lymphoma

DNA replication licensing in somatic and germ cells

Mcm2, Geminin, and KI67 define proliferative state and are prognostic markers in renal cell carcinoma

DNA replication licensing in peripheral B-cell lymphoma

Repression of DNA replication licensing in quiescence is independent of geminin and may define the cell cycle state of progenitor cells

DNA replication licensing and cell cycle kinetics of normal and neoplastic breast

Novel markers of cell kinetics to evaluate progression from cirrhosis to hepatocellular carcinoma

Small-molecule mimics of an alpha-helix for efficient transport of proteins into cells

DNA replication licensing, and survival are linked in prostate cancer

Mitogenic growth signalling, DNA replication licensing, and survival are linked in prostate cancer

Hexameric ring structure of human MCM10 DNA replication factor

DNA replication licensing factors and aurora kinases are linked to aneuploidy and clinical outcome in epithelial ovarian carcinoma.

Cell cycle markers in clinical oncology

Identification of an arginine-rich motif in human papillomavirus type 1 E1;E4 protein necessary for E4-mediated inhibition of cellular DNA synthesis in vitro and in cells

Diagnosis of pancreaticobiliary malignancy by detection of minichromosome maintenance protein 5 in bile aspirates

Modular assembly using sequential palladium coupling gives easy access to the SMoC class of cellular transporters

Cell-cycle-phase progression analysis identifies unique phenotypes of major prognostic and predictive significance in breast cancer

Phospho-STAT5 and phospho-Akt expression in chronic myeloproliferative neoplasms

Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma

DNA replication licensing factors and aneuploidy are linked to tumor cell cycle state and clinical outcome in penile carcinoma

Standard Reference Material: Cell Line Development and Use of Reference Cell Lines as Standards for External Quality Assurance of Her2 IHC and ISH Testing. Antigen Retrieval Immunohistochemistry Based Research and Diagnostics (Book)

Diagnosis of prostate cancer by detection of minichromosome maintenance 5 protein in urine sediments

Targeting DNA replication before it starts: Cdc7 as a therapeutic target in p53-mutant breast cancers

Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)-beta-TrCP, sequentially regulate glycolysis during the cell cycle

Molecular architecture of the DNA replication origin activation checkpoint

Exploring the interaction between siRNA and the SMoC biomolecule transporters: implications for small molecule-mediated delivery of siRNA

The cell cycle and cancer

Bladder cancer diagnosis and identification of clinically significant disease by combined urinary detection of Mcm5 and nuclear matrix protein 22

Subcellular proteomics reveals a role for nucleo-cytoplasmic trafficking at the DNA replication origin activation checkpoint

Pregnancy-associated plasma protein A regulates mitosis and is epigenetically silenced in breast cancer

Do Cell-Cycle Phase-Specific Markers Predict Disease Grade, Stage, and Outcome in Cervical Carcinoma?

Cdc7 is a potent anti-cancer target in pancreatic cancer due to abrogation of the DNA origin activation checkpoint

Cell cycle status in AML blast cells from peripheral blood, bone marrow aspirates and trephines and implications for biological studies and treatment

p53 controls CDC7 levels to reinforce G1 cell cycle arrest upon genotoxic stress

A comparative study of PD-L1 diagnostic assays in squamous cell carcinoma of the head and neck (SCCHN)