Research & Development Programmes

In house bioanalytical R&D services focused on development of novel diagnostic and therapeutic intervention strategies targeting the cell cycle machinery.

Theranostic patient-centered strategies are often directed against complex and redundant growth signalling networks from surface ligands and receptors through transducers to downstream effector molecules.

However the redundancy of these networks can result in low efficacy of molecularly targeted drugs and constraints on the performance of cancer biomarkers directed at these pathways.

Oncologica’s alternative genetic testing approach is to target the cell cycle machinery, which acts as a convergence point for information transduced through upstream signalling networks and therefore represents an exceptionally attractive diagnostic and therapeutic target.

Research Papers

Molecular structure of human geminin

Molecular structure of human geminin

Nat Struct Mol Biol. 2004 Oct;11(10):1021-2.

Okorokov AL, Orlova EV, Kingsbury SR, Bagneris C, Gohlke U, Williams GH, Stoeber K.

Diagnosis of oesophageal cancer by detection of minichromosome maintenance 5 protein in gastric aspirates

Diagnosis of oesophageal cancer by detection of minichromosome maintenance 5 protein in gastric aspirates

Br J Cancer. 2004 Aug 16;91(4):714-9.

Williams GH, Swinn R, Prevost AT, De Clive-Lowe P, Halsall I, Going JJ, Hales CN, Stoeber K, Middleton SJ.

Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments

Diagnosis of genito-urinary tract cancer by detection of minichromosome maintenance 5 protein in urine sediments

J Natl Cancer Inst. 2002 Jul 17;94(14):1071-9.

Stoeber K, Swinn R, Prevost AT, de Clive-Lowe P, Halsall I, Dilworth SM, Marr J, Turner WH, Bullock N, Doble A, Hales CN, Williams GH.

Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer

Minichromosome maintenance protein 2 expression in prostate: characterization and association with outcome after therapy for cancer

Clin Cancer Res. 2001 Sep;7(9):2712-8.

Meng MV, Grossfeld GD, Williams GH, Dilworth S, Stoeber K, Mulley TW, Weinberg V, Carroll PR, Tlsty TD.

DNA replication licensing and human cell proliferation

DNA replication licensing and human cell proliferation

J Cell Sci. 2001 Jun;114(Pt 11):2027-41.

Stoeber K, Tlsty TD, Happerfield L, Thomas GA, Romanov S, Bobrow L, Williams ED, Williams GH.

Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine

Immunoassay for urothelial cancers that detects DNA replication protein Mcm5 in urine

Lancet. 1999 Oct 30;354(9189):1524-5.

Stoeber K, Halsall I, Freeman A, Swinn R, Doble A, Morris L, Coleman N, Bullock N, Laskey RA, Hales CN, Williams GH.

Minichromosome maintenance proteins as biological markers of dysplasia and malignancy

Minichromosome maintenance proteins as biological markers of dysplasia and malignancy

Clin Cancer Res. 1999 Aug;5(8):2121-32.

Freeman A, Morris LS, Mills AD, Stoeber K, Laskey RA, Williams GH, Coleman N.

Clinical applications of a novel mammalian cell-free DNA replication system

Clinical applications of a novel mammalian cell-free DNA replication system

Br J Cancer. 1999 Jul;80 Suppl 1:20-4.

Williams G, Stoeber K.

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system

Cdc6 protein causes premature entry into S phase in a mammalian cell-free system

EMBO J. 1998 Dec 15;17(24):7219-29.

Stoeber K, Mills AD, Kubota Y, Krude T, Romanowski P, Marheineke K, Laskey RA, Williams GH.

Improved cervical smear assessment using antibodies against proteins that regulate DNA replication

Improved cervical smear assessment using antibodies against proteins that regulate DNA replication

Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14932-7.

Williams GH, Romanowski P, Morris L, Madine M, Mills AD, Stoeber K, Marr J, Laskey RA, Coleman N.

The Hormonal Receptor Status of Uterine Carcinosarcomas (Mixed Mullerian Tumours): an Immunohistochemical study

The Hormonal Receptor Status of Uterine Carcinosarcomas (Mixed Mullerian Tumours): an Immunohistochemical study

Journal of Clinical Pathology, April 1997, Vol. 50: No.4, p328-331 DOI: https://dx.doi.org/10.1136%2Fjcp.50.4.328

A.C. Ansink, P.A. Cross, P. Scorer et al (1997)